doseselection
Doseselection is the process of determining the appropriate dose of a drug or other therapeutic agent for clinical use or research, with the aim of achieving therapeutic benefit while minimizing safety risks. It encompasses the selection of a dose level or range to be studied or prescribed, informed by pharmacology, prior data, and clinical judgment.
In drug development, dose selection typically follows early-phase studies that test multiple dose levels to characterize
In clinical practice, approved dosing regimens are specified in product labeling, with adjustments for factors such
Key considerations include interindividual variability in drug metabolism, safety thresholds, therapeutic window, and the balance of
See also: dose-ranging study, dose-escalation, maximum tolerated dose, recommended phase 2 dose, pharmacokinetics.