dimB
DimB is a gene symbol used in multiple organisms, most notably in the social amoeba Dictyostelium discoideum, where it encodes a transcription factor involved in DIF-1–mediated development. DimB is a basic leucine zipper (bZIP) transcription factor that participates in the DIF-1 signaling pathway, which governs cell-fate decisions during Dictyostelium development. In response to differentiation-inducing factor-1 (DIF-1), DimB relocalizes to the nucleus and helps regulate the transcription of genes associated with prestalk differentiation, contributing to the patterning of the fruiting body. Genetic disruption of dimB in Dictyostelium often results in altered morphogenesis and defects in DIF-1–dependent gene expression, underscoring its role in developmental regulation. DimB activity is modulated by signaling inputs and post-translational modifications that influence its DNA-binding and nuclear localization.
Because gene symbols are not unique across species, dimB may refer to different, unrelated genes in other