cytoskeletondriven

Cytoskeleton-driven refers to cellular processes and mechanical activities powered by the cytoskeleton, a dynamic network of protein filaments that provides structural support, organizes intracellular space, and generates force. The cytoskeleton comprises actin filaments, microtubules, and intermediate filaments, each contributing to different mechanical tasks. Movement and remodeling are driven by polymerization and depolymerization and by motor proteins, including myosin on actin and kinesin and dynein on microtubules, which convert chemical energy into force and movement.

In cell motility, actin polymerization at the leading edge produces protrusions such as lamellipodia and filopodia, while contractile forces mediated by myosin pull the cell body forward. Intracellular transport relies on motor proteins carrying vesicles, organelles, and other cargo along microtubules and actin networks. Cytoskeletal dynamics also drive cell division, with microtubules forming the mitotic spindle and actin organizing the contractile ring during cytokinesis. Growth, differentiation, and morphogenesis involve cytoskeleton-driven shape changes and polarity establishment. Neuronal growth cones remodel actin and microtubule networks to guide axon navigation. Cilia and flagella beating is powered by dynein motors along axonemal microtubules.

The cytoskeleton responds to signaling cues and mechanical forces, integrating metabolic input with structural rearrangements. Dysregulation of cytoskeleton-driven processes is linked to diseases such as cancer, neurodegeneration, and developmental disorders, highlighting the central role of this machinery in health and disease. The term cytoskeleton-driven (or cytoskeletondriven) thus encompasses a broad set of processes essential to cell function and morphogenesis.