cohesinien
Cohesinien are multisubunit protein complexes essential for sister chromatid cohesion, DNA repair, transcriptional regulation, and higher-order genome organization. They form a ring-like structure that encircles sister chromatids after DNA replication, helping hold them together until separation in anaphase.
Composition: The core cohesin ring comprises Smc1 and Smc3, which form an elongated V-shaped heterodimer, connected
Assembly and regulation: Cohesin is loaded onto chromatin by the Scc2/Scc4 loader complex. In S phase, Eco1/CTF7
Roles: Beyond cohesion, cohesinien participate in DNA repair via homologous recombination, regulate gene expression, and contribute
Clinical and evolutionary context: Mutations affecting cohesin components or regulators underlie cohesinopathies such as Cornelia de