clomipramin
Clomipramin, also spelled clomipramine, is a tricyclic antidepressant (TCA) used in the treatment of mood disorders and obsessive-compulsive disorder (OCD). It is generally considered after other treatments, such as selective serotonin reuptake inhibitors (SSRIs), have been ineffective or poorly tolerated.
Mechanism of action and pharmacology
Clomipramin inhibits the reuptake of serotonin more potently than norepinephrine, increasing serotonin signaling in the brain.
The primary indication for clomipramin is OCD, where it is effective in reducing obsessive and compulsive symptoms.
Common adverse effects include dry mouth, constipation, urinary retention, blurred vision, sedation, weight gain, dizziness, and
Pharmacokinetics and interactions
Clomipramin is absorbed orally and metabolized in the liver, forming active metabolites such as norclomipramine. The