cholesterolconjugated
Cholesterolconjugated refers to molecules that carry a cholesterol moiety covalently attached to another chemical entity. This conjugation can involve drugs, peptides, nucleic acids, lipids, imaging probes, or nanoparticles, and is used to modify physicochemical properties and biological behavior.
The addition of cholesterol often increases lipophilicity and promotes association with lipid membranes and circulating lipoproteins.
Chemistry and design considerations include the site of attachment, the nature of the linker, and the type
Applications and examples span nucleic acid therapeutics, where cholesterol-conjugated siRNA or antisense oligonucleotides show enhanced in