centrin1

Centrin1 is a member of the centrin family of calcium-binding proteins, which are highly conserved across eukaryotic species. These proteins are characterized by their EF-hand motifs that allow them to bind calcium ions, playing crucial roles in various cellular processes. Centrin1 is primarily involved in centrosome duplication and microtubule organization, contributing to the structural integrity and function of the centrosome, which is vital for accurate cell division.

Centrin1 is typically localized to the centrosome and basal bodies, where it participates in the regulation and stabilization of these organelles. Its function is closely associated with the formation and maintenance of the microtubule network, influencing cell shape, motility, and intracellular transport. In addition to its structural roles, centrin1 has been implicated in DNA damage response pathways, although its precise molecular mechanisms remain under investigation.

Research indicates that centrin1 interacts with other centrosomal proteins and participates in the assembly of the peri-centriolar material. Its expression levels are generally cell cycle-dependent, peaking during phases of centrosome duplication. Mutations or dysregulation of centrin1 are linked to errors in cell division, which can contribute to genomic instability and are associated with certain diseases, including cancer.

Throughout evolution, centrin proteins have diversified, but their core functions related to calcium signaling and centrosome dynamics have been preserved. Due to its fundamental role in cell cycle regulation, centrin1 continues to be a significant subject of cellular and molecular biology studies, especially concerning cell division and its implications in health and disease.