celastrol
Celastrol is a natural pentacyclic triterpenoid isolated from Tripterygium wilfordii, also called the Thunder God Vine. It has attracted interest for anti-inflammatory, immunomodulatory and anti-cancer properties observed in preclinical studies.
Chemically, celastrol contains a reactive quinone methide–type moiety, contributing to its electrophilic reactivity with thiol groups
Biological activity: Celastrol inhibits NF-κB signaling and modulates JAK/STAT and MAPK pathways; it can activate the
In preclinical models, celastrol reduces inflammatory cytokine production, exerts anti-tumor effects in various cancer cell lines,
Safety and regulatory status: Celastrol carries substantial toxicity risks observed in animal studies, including hepatotoxicity and