carmustine

Carmustine, also known by its trade name BiCNU, is an alkylating agent used in chemotherapy. It is a derivative of nitrogen mustard and works by cross-linking DNA, which inhibits cell division and ultimately leads to cell death. Carmustine is commonly used in the treatment of brain tumors, particularly glioblastoma multiforme, and is often administered via an implantable device called a Gliadel wafer. This wafer releases carmustine directly into the tumor site, allowing for higher concentrations of the drug to be delivered locally. Carmustine is typically administered in combination with other chemotherapy agents to enhance its efficacy. The drug is available in various formulations, including an intravenous solution and a wafer for local delivery. Carmustine has been studied extensively for its efficacy and safety in the treatment of brain tumors, and its use continues to be a topic of ongoing research.