BiCNU

BiCNU, also known as bis(chloronitroso)urea, is a chemical compound with the formula (ClNNO)2C(NH2)2. It is a white crystalline solid that is highly toxic and explosive. BiCNU is a prodrug, meaning it is inactive until it is metabolized in the body. Once metabolized, it releases chloroacetaldehyde, which is responsible for its cytotoxic effects. BiCNU is primarily used as an anticancer agent, particularly in the treatment of brain tumors. It is administered intravenously and has a half-life of about 10 minutes in the bloodstream. The drug is known to cause side effects such as nausea, vomiting, and hair loss. BiCNU is also used in the synthesis of other chemical compounds, although this use is less common. The compound was first synthesized in the 1960s and has since been studied extensively for its potential therapeutic applications. However, its use is limited due to its toxicity and the development of alternative treatments. BiCNU is classified as a Schedule III drug in the United States, indicating a potential for abuse and dependence. It is important to note that BiCNU should only be used under the supervision of a healthcare professional.