bronchokonstriktive
Bronchokonstriktiva, or bronchoconstrictors, are substances that cause narrowing of the airways by constricting bronchial smooth muscle. They are the opposite of bronchodilators, which widen the airways. Bronchoconstriction can be triggered by endogenous mediators released during inflammatory or allergic responses, as well as by exogenous agents and environmental factors.
Mechanism of action involves stimulation of receptors on airway smooth muscle and surrounding tissues. Histamine and
Examples include endogenous mediators such as histamine, leukotrienes C4, D4, and E4, and prostaglandin F2alpha. Pharmacologic
Clinical relevance lies in the role of bronchoconstriction in diseases such as asthma and anaphylaxis, where