biliarkanalikuli
Biliarkanalikuli, known in English as bile canaliculi, are microscopic channels that form the first functional units of the biliary tree within the liver. They are located in the hepatic lobules and arise from the apical surfaces of adjacent hepatocytes, creating a network through which bile produced by hepatocytes is collected and directed toward the larger biliary ducts via the canal of Hering and interlobular bile ducts in the portal tract.
Anatomically, bile canaliculi are bounded by tight junctions between neighboring hepatocytes, so the lumen is formed
Physiologically, canalicular bile formation involves transport proteins on the canalicular membrane. Key players include BSEP (bilir
Clinically, dysfunction of canalicular secretion or obstruction of the downstream ducts can lead to intrahepatic cholestasis,