beta2selective
Beta2selective refers to pharmacological agents that preferentially interact with the beta-2 adrenergic receptor (β2-AR) over other adrenergic receptor subtypes, particularly beta-1 (β1-AR). These ligands are described as beta-2 selective when their affinity or efficacy at β2 receptors is greater than at β1 or β3 receptors. Selectivity is often relative and dose-dependent, with higher concentrations potentially engaging non-target receptors.
Mechanism of action for β2-selective agonists involves stimulation of the Gs protein–adenylyl cyclase–cAMP pathway. In airway
Clinical use distinguishes short-acting beta-2 agonists (SABAs) such as albuterol (salbutamol) and terbutaline for rapid relief,
Selectivity is an important concept in drug design and clinical practice, as many beta-agonists vary in their