beta2adrenerga
Beta2adrenerga refers to the beta-2 adrenergic receptor (β2-AR), a G protein-coupled receptor that binds catecholamines such as epinephrine and norepinephrine. In humans, the receptor is encoded by the ADRB2 gene and is expressed in various tissues, with high levels in bronchial and vascular smooth muscle, as well as in the uterus, skeletal muscle, and certain immune and metabolic cells.
Function and signaling: upon activation, β2-AR couples to the stimulatory G protein (Gs), stimulating adenylyl cyclase
Pharmacology and clinical relevance: selective β2-adrenergic agonists, including salbutamol (albuterol), formoterol, and salmeterol, are widely used
Genetics and variability: common polymorphisms in ADRB2, such as Arg16Gly and Gln27Glu, have been studied for