auxetilization
Auxetilization is a process of partial methylation of a base, commonly referring to the methylation of nucleosides. This process involves replacing the amino group of a base with a methyl group, resulting in a molecule with an additional methylated nitrogen atom and a reduced positive charge at physiological pH.
In the context of nucleosocide chemistry, auxetilization is a useful method for introducing a protective group
The protecting group introduced during auxetilization acts as a stabilizing entity, preventing the naturally occurring chemical
The biological activity of the base may be affected by the additional methyl group, allowing for the