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Autophagosomes are membrane-bound organelles that play a crucial role in cellular homeostasis and quality control. They are formed through a process called autophagy, which is a highly conserved cellular pathway that degrades and recycles damaged organelles, misfolded proteins, and other cellular components. Autophagosomes are generated by the sequestration of cytoplasmic contents within a double-membrane structure, which is then delivered to the lysosome for degradation.
The formation of autophagosomes involves the coordination of several key proteins, including Beclin-1, Atg5, Atg7, and
Autophagy is essential for maintaining cellular health and is implicated in various physiological and pathological processes.
The study of autophagosomes and autophagy has advanced significantly in recent years, with the identification of