antiösztrogének

Antiösztrogének, also known as antiestrogens, are a class of drugs that block the effects of estrogen in the body. They work by binding to estrogen receptors, preventing estrogen from attaching and exerting its actions. This blockade can be partial or complete, depending on the specific antiöstrogen.

These compounds are primarily used in the treatment of hormone-sensitive cancers, particularly breast cancer. By reducing the stimulation of cancer cells by estrogen, antiöstrogének can help to slow or stop tumor growth. They are also used in fertility treatments to stimulate ovulation and in the management of certain gynecological conditions.

There are several types of antiöstrogének, with selective estrogen receptor modulators (SERMs) being a prominent class. Tamoxifen is a well-known SERM that acts as an antiöstrogen in breast tissue but can have estrogenic effects in other parts of the body, such as the uterus and bones. Aromatase inhibitors are another group of drugs that reduce estrogen levels by blocking the enzyme aromatase, which is responsible for estrogen production.

Side effects of antiöstrogének can vary depending on the specific drug and individual patient. Common side effects may include hot flashes, vaginal dryness, and an increased risk of blood clots. In some cases, they can also affect bone density and mood. The use of antiöstrogének requires careful monitoring by a healthcare professional to manage potential risks and optimize treatment outcomes.