alfa14linkage
Alfa14linkage is a term used in polymer chemistry to describe a hypothetical covalent connection between two molecular segments that uses a fixed fourteen-atom spacer to fix relative orientation between the segments. The name combines 'alfa' for angular alignment and '14' referring to the spacer length.
Conceptual model: The alfa14 linkage is formed by a bifunctional spacer that can react with complementary groups
Synthesis: In theory, the linkage could be introduced via solid-phase synthesis or solution-phase chemistry, employing orthogonal
Applications: Potential use in protein scaffolds, synthetic polymers, and hydrogels where defined intersegment angles improve mechanical
Status and debate: Alfa14linkage remains largely theoretical in the literature, with limited experimental demonstration. Some researchers
See also: covalent crosslinking, spacer arm, click chemistry, protein engineering, polymer physics.