acetylkolintransportören
The acetylkolintransportören, also known as the choline transporter or CHT, is a protein responsible for the reuptake of choline from the synaptic cleft into presynaptic neurons. This process is crucial for the synthesis of acetylcholine (ACh), a vital neurotransmitter involved in a wide range of physiological functions, including muscle contraction, learning, memory, and attention.
The CHT is a high-affinity transporter that utilizes a sodium gradient to drive the uptake of choline.
Dysfunction of the CHT has been implicated in several neurological disorders. For example, reduced CHT activity
The structure of the CHT has been elucidated through cryo-electron microscopy, revealing a complex transmembrane protein