ZeroOrderFreisetzung
ZeroOrderFreisetzung, or zero-order release, is a drug release mechanism in which the amount of drug released per unit time remains constant, independent of the remaining amount within the dosage form. In mathematical terms, the release rate dM/dt is constant (k0), leading to a linear increase of the cumulative amount released M(t) over time. This is in contrast to first-order release, where the rate decreases as the available drug is depleted. In practice, zero-order release is an idealization; many systems approximate zero-order behavior for a portion of their life span.
Achieving true zero-order release requires careful design to maintain a constant driving force and surface area
Applications of zero-order release concepts include long-term drug therapies, pain management, and treatments requiring tight concentration