ZMS20

ZMS20, also known as Zinc Metallothionein-20, is a protein found in various organisms, including humans, that plays a crucial role in metal homeostasis and detoxification. It is a member of the metallothionein family, which are small, cysteine-rich proteins that bind to heavy metals such as zinc, copper, cadmium, and mercury. ZMS20 is characterized by its high affinity for zinc and its ability to regulate zinc levels in cells.

The gene encoding ZMS20 is located on chromosome 19 in humans. The protein consists of 61 amino acids and is highly conserved across different species. ZMS20 is primarily expressed in the liver, kidney, and brain, where it helps maintain zinc levels necessary for various physiological processes, including immune function, DNA synthesis, and protein synthesis.

Mutations in the ZMS20 gene have been linked to several genetic disorders, including acrodermatitis enteropathica, a rare autosomal recessive disorder characterized by skin lesions, diarrhea, and growth failure. Additionally, ZMS20 has been implicated in the pathogenesis of certain cancers, as its expression levels can influence cell proliferation and differentiation.

Research on ZMS20 is ongoing, with studies focusing on its potential as a therapeutic target for metal-related diseases and cancer. Understanding the molecular mechanisms underlying ZMS20 function and regulation is essential for developing effective treatments for these conditions.