VKORC11699GA

VKORC11699GA refers to a specific genetic variation, a single nucleotide polymorphism (SNP), within the VKORC1 gene. This gene, Vitamin K Epoxide Reductase Complex Subunit 1, plays a crucial role in the vitamin K cycle, which is essential for the synthesis of blood clotting factors. The VKORC1 gene encodes a protein that recycles vitamin K, enabling it to participate in the carboxylation of these clotting factors.

The rs11699GA designation is a reference number for this particular SNP, indicating a change from guanine (G) to adenine (A) at a specific position within the VKORC1 gene. This particular variation is of interest in pharmacogenetics, particularly concerning the anticoagulant warfarin. Warfarin's efficacy and the risk of bleeding are influenced by genetic factors, and variations in VKORC1 are well-established contributors to this variability. Individuals with certain VKORC1 genotypes, including those related to rs11699GA, may require different initial doses of warfarin to achieve therapeutic anticoagulation safely and effectively. Understanding these genetic variations can help clinicians personalize warfarin therapy, potentially reducing the risk of adverse events. Research in this area continues to refine the understanding of how VKORC1 SNPs impact drug response.