VAR20236789

VAR20236789 is a designation in the Variant Archive (VAR), a fictional database used in this article to illustrate standard practices for reporting genetic variants. The entry corresponds to a single-nucleotide variant identified in sequencing data from a 2023 population study. The naming convention combines the prefix VAR with the year of discovery and a serial number, yielding VAR20236789.

Genomic features: The variant is classified as a single-nucleotide variant (SNV) located on chromosome 3 at position 9,476 in the reference genome, within the coding sequence of gene VAR1. The reference allele is C and the alternate allele is T. The substitution results in a non-synonymous amino acid change from leucine to phenylalanine at residue 316, with potential functional implications under certain conditions.

Population data and quality: The variant has a low allele frequency, reported at about 3.2% across sequenced samples from three regions. Sequencing depth across samples shows a median coverage around 28x, and the record carries standard quality flags according to VAR reporting guidelines. Evidence for the variant comes from two independent observations, each passing basic replicability checks.

Impact and status: Currently VAR20236789 is considered a provisional finding with unclear phenotypic effects. Functional predictions are mixed, and no confirmed phenotype association exists. The entry serves as an example of how variant records are structured, validated, and interpreted, emphasizing the need for context such as sample origin, experimental design, and corroborating data when drawing conclusions.

See also: Variant Archive (VAR), single-nucleotide variant, variant nomenclature.