Tyr580581

Tyr580581 is a notational reference used in protein sequence data to identify two adjacent tyrosine residues, Tyr-580 and Tyr-581, within a larger protein. The numbering is specific to the protein sequence and is not universal across proteins. The term is commonly encountered in phosphorylation studies and in database annotations that map post-translational modifications to residue positions.

In many signaling proteins, tyrosine residues can be phosphorylated by protein tyrosine kinases. A tandem arrangement such as Tyr-580/Tyr-581 can serve as a phosphorylation motif that modulates binding interactions with SH2-domain proteins, recruits signaling partners, or influences catalytic activity. The functional outcome is highly dependent on the surrounding sequence and structural context.

Because residue numbering is protein-specific, Tyr580/581 refers to a site within a particular protein, not a standalone entity. Different species or isoforms may shift the positions or omit one of the residues. Researchers describe such sites in phosphorylation maps, with functional assays or mass spectrometry confirming their modification state.

Examples of potential roles include regulation of receptor signaling, cytoskeletal organization, or adapter protein interactions. Phosphorylation at adjacent tyrosines can also affect local conformations, creating or masking docking surfaces. Any interpretation of Tyr580581 therefore requires the protein context and experimental evidence.

See also: phosphotyrosine, SH2 domain, receptor tyrosine kinase, post-translational modification.