TypIIFAS
TypIIFAS is a term used in biochemistry to denote a proposed subclass of type II fatty acid synthase (FAS) systems. It is distinguished from both the canonical Type II fatty acid synthase arrangements and the Type I multifunctional megasynthases by its modular, ACP-dependent organization. In TypIIFAS, fatty acid elongation relies on separate, typically soluble enzymes that act on an acyl carrier protein (ACP) carrying the growing chain. Condensation is performed by ketoacyl-ACP synthases (KAS) of the II-type (such as FabB/FabF homologs), with individual enzymes providing distinct steps: malonyl transfer (FabD-like), reduction (FabG), dehydration (FabZ/FabA), and enoyl reduction (FabI). The pathway proceeds through sequential cycles with the growing acyl-ACP tethered to ACP rather than existing as a single polypeptide.
Occurrence and genetic organization: TypIIFAS components have been identified in several bacterial genera and, in some
Function and importance: TypIIFAS contributes to membrane lipid biosynthesis and can be adapted for the production