Tubulinbased
Tubulin-based refers to cellular and molecular systems that rely on tubulin proteins, particularly alpha- and beta-tubulin, which assemble into microtubules. These tubulin-based polymers form a dynamic cytoskeletal network that underpins cell shape, intracellular transport, and division. In most eukaryotic cells, microtubules originate from microtubule organizing centers, with gamma-tubulin playing a key nucleation role. The polymers are formed from alpha/beta-tubulin dimers bound to GTP, with GTP hydrolysis driving dynamic instability.
Microtubules are hollow tubes built from protofilaments; they exhibit growth and shrinkage, termed catastrophe and rescue.
Post-translational modifications of tubulin, including acetylation, detyrosination, and polyglutamylation, influence stability and interactions with motors and
Beyond cell division, tubulin-based networks organize the mitotic spindle, cilia, and flagella, and participate in signaling