Trägerstoffe

Trägerstoffe, also known as excipients, are inactive ingredients added to pharmaceutical formulations. They serve a variety of functions beyond simply carrying the active pharmaceutical ingredient (API). These functions are crucial for the effective delivery, stability, and manufacturability of medications.

Common roles of Trägerstoffe include acting as diluents to increase the bulk of a dosage form, making it easier to handle and administer, especially for potent APIs present in small quantities. They can also function as binders, helping to hold tablets together, or as disintegrants, facilitating the breakdown of tablets in the body to release the API. Lubricants are another important class, preventing sticking during tablet manufacturing.

Furthermore, Trägerstoffe can enhance the stability of the API by protecting it from degradation due to moisture, light, or oxidation. They can also influence the rate of drug release, allowing for immediate or sustained delivery depending on the therapeutic need. Other roles include improving palatability of oral medications, aiding in the flow of powders, and providing color or texture. The selection of appropriate Trägerstoffe is a critical step in drug formulation, impacting safety, efficacy, and patient compliance.