Thr187

Thr187 refers to Threonine at position 187 within a protein sequence. Threonine is one of the 20 standard amino acids, characterized by its hydroxyl group. This hydroxyl group makes threonine residues capable of participating in various post-translational modifications, such as phosphorylation, glycosylation, and ubiquitination. These modifications can significantly alter a protein's structure, function, and interactions.

The specific amino acid at position 187, threonine, can play a crucial role in the protein's overall behavior. For instance, if Thr187 is a site of phosphorylation, its altered charge state can influence protein folding, its ability to bind to other molecules, or its activity within a cellular pathway. Researchers might study Thr187 to understand its involvement in disease mechanisms, as aberrant phosphorylation at such sites is often linked to conditions like cancer or neurodegenerative disorders.

Identifying whether a threonine residue is conserved across different species or orthologous proteins can also provide clues about its functional importance. Highly conserved residues are often indicative of critical roles. Therefore, Thr187 is not just a position in a linear sequence but a specific residue with the potential to be a key player in protein function and regulation, often investigated through biochemical and genetic approaches.