Tensin4

Tensin4 is a protein encoded by the TNS4 gene in humans. It belongs to the tensin family of proteins, which are known for their roles in cell adhesion, migration, and cytoskeletal organization. Tensin4 is characterized by the presence of a Src homology 2 (SH2) domain, a serine/threonine kinase domain, and a C-terminal actin-binding domain. These structural features suggest its involvement in signaling pathways that regulate cell behavior.

The TNS4 gene is located on chromosome 11. The Tensin4 protein is expressed in various tissues, with particularly notable expression in the nervous system. Research indicates that Tensin4 plays a role in neuronal development, synaptic plasticity, and the regulation of cell growth. Dysregulation of Tensin4 has been implicated in certain neurological disorders and cancers, suggesting its potential as a therapeutic target. Further research is ongoing to fully elucidate the complex functions of Tensin4 in normal physiology and disease states.