TYROBP
TYROBP, also known as T-cell immunoglobulin and mucin domain-containing protein B, is a gene that encodes a cytoplasmic adaptor protein involved in immune signaling pathways. The protein product, often referred to as DAP12 or KARAP, plays a crucial role in the activation and regulation of myeloid cells, including macrophages, microglia, and natural killer (NK) cells.
Structurally, TYROBP contains a cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM), which allows it to associate with
Mutations or dysregulation of TYROBP have been linked to several neurological and immune disorders. For example,
In research, TYROBP continues to be a subject of interest for its role in immune cell signaling
Overall, TYROBP is a pivotal protein in immune regulation, with significant implications for neurological health and