TP53mutated
TP53mutated refers to the presence of mutations in the TP53 gene. The TP53 gene, located on chromosome 17, encodes a tumor suppressor protein known as p53. This protein plays a crucial role in maintaining genomic stability by regulating cell cycle progression, DNA repair, and apoptosis. When TP53 is mutated, the p53 protein can become inactivated or acquire new oncogenic functions.
Mutations in TP53 are among the most frequent genetic alterations found in human cancers. They occur in
The consequences of TP53 mutations are multifaceted. Loss of normal p53 function can lead to uncontrolled cell
The presence of TP53 mutations is often associated with a poorer prognosis and a less favorable response