TNFreceptorsuperfamiljen
The TNF receptor superfamily (TNFRSF) comprises a large group of type I transmembrane receptors that bind ligands of the tumor necrosis factor (TNF) superfamily. Members regulate immune cell development, survival, differentiation, and death. Most TNFRSF members share extracellular cysteine-rich domains and intracellular motifs that determine signaling outcomes; several include a death domain that can recruit adaptor proteins to initiate apoptosis.
Upon ligand binding, many TNFRSF receptors form trimers or higher-order complexes, recruiting adaptor proteins such as
Functionally, TNFRSF signaling controls lymphoid organ development, B and T cell activation, dendritic cell function, and
Clinically, TNFRSF pathways are implicated in cancer, autoimmunity, and infectious diseases. Therapeutic strategies include TNF inhibitors