TFIID
TFIID, or the TATA-binding protein (TBP) and TBP-associated factors complex, is a crucial general transcription factor that plays a fundamental role in the initiation of transcription by RNA polymerase II in eukaryotes. It is a multi-subunit protein complex that recognizes and binds to the TATA box, a DNA sequence commonly found in the promoter regions of many genes. This binding event serves as a platform for the assembly of other transcription machinery components.
The TFIID complex consists of TBP, which is the subunit responsible for TATA box recognition, and a
Upon binding to the promoter, TFIID distorts the DNA helix, which facilitates the recruitment of additional