TAK1TAB
TAK1TAB refers to the signaling module formed by TAK1 (MAP3K7) and its TAK1-binding proteins, TAB1 (MAP3K7IP1), TAB2 (MAP3K7IP2), and TAB3 (MAP3K7IP3). The TAK1TAB complex plays a central role in transducing signals from innate immune receptors such as IL-1, TNF, Toll-like receptors and other pattern-recognition pathways, leading to activation of inflammatory transcription programs.
In unstimulated cells TAK1 forms complexes with TAB proteins, and upon receptor engagement TAB2 and TAB3 recognize
Structure and regulation: TAB1 contains a TAK1-binding region and domains that support TAK1 activation, while TAB2
Clinical relevance: Dysregulation of the TAK1TAB module has been linked to inflammatory diseases and certain cancers.