T83A
T83A is a designation used in molecular biology to denote a specific amino acid substitution in a protein: the threonine at position 83 is replaced by alanine. The notation follows the standard convention in protein mutation reporting, where the initial letter represents the wild-type amino acid, the number indicates the residue position, and the final letter identifies the mutant amino acid.
The exact effect of a T83A substitution depends on the protein and its context. Because threonine bears
In research, T83A is typically introduced by site-directed mutagenesis to study the role of that specific residue.
Not all T83A substitutions have clinical significance; their relevance is determined by the protein, organism, and
See also: missense mutation, amino acid substitution, site-directed mutagenesis, protein function.