Surrogatemärke

Surrogatemärke, also known as surrogate markers, are chemical compounds used in analytical chemistry to identify and quantify specific substances in a mixture. They are particularly useful in gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) techniques. Surrogatemärke are designed to mimic the behavior of the target analytes in the sample matrix, allowing for accurate calibration and quantification.

The selection of an appropriate surrogatemärke is crucial for the success of the analysis. It should have similar physical and chemical properties to the target analytes, such as volatility, polarity, and mass spectral fragmentation patterns. This ensures that the surrogate marker behaves identically to the analyte during the separation and detection processes.

Surrogatemärke are typically added to the sample at a known concentration before extraction and analysis. By measuring the response of the surrogate marker, analysts can correct for variations in sample preparation, instrument response, and other potential sources of error. This leads to more accurate and reliable results.

In some cases, multiple surrogatemärke may be used to cover a range of analytes with different properties. This approach enhances the robustness of the method and improves the overall quality of the data obtained.

The use of surrogatemärke is a standard practice in many analytical laboratories, ensuring that the results are both precise and accurate. By incorporating surrogate markers into their analytical protocols, laboratories can achieve higher confidence in their measurements and better reproducibility of results.