Sulamised

Sulamised is an adjective used in organic chemistry to describe a molecule that has undergone sulamidation, i.e., the introduction of a sulfonamide group (-SO2NRR') into the molecule. The term is relatively uncommon and not widely standardized; more commonly, chemists would say the compound is sulfonamidated or that sulfonamide groups have been installed.

In practice, sulamidation is employed to modify the properties of a molecule, such as increasing hydrophilicity, altering pharmacokinetic properties, or enabling hydrogen-bonding interactions in biological targets. Sulfonamide groups are a core motif in medicinal chemistry and are present in many pharmaceuticals, agrochemicals, and polymers.

General approach: a substrate bearing an amino group is treated with a sulfonylating agent (for example a sulfonyl chloride or a sulfonyl fluoride) to form the sulfonamide linkage. Reactions are typically conducted under basic or neutral conditions, and the choice of sulfonylating reagent determines the sulfonamide's substituents. This description remains at a high level and does not provide laboratory instructions.

Limitations: the term "sulamised" is not universally used and may be encountered mainly in specialized papers or older literature; readers may instead see "sulfonamidated" or "sulfonamide-substituted."

See also: sulfonamide, sulfonamidation, sulfonyl chloride, sulfonyl fluoride, sulfonation.