SipBs
SipBs refers to the group of SipB proteins, translocator components associated with the type III secretion system (T3SS) of Salmonella species. SipB is encoded within the Salmonella pathogenicity island 1 (SPI-1) and functions together with SipC to form the translocation pore in host cell membranes, through which effector proteins are delivered into the cytosol of host cells. The SipB/SipC complex embeds in the host membrane to create a channel that enables the injection of virulence factors capable of manipulating host cell processes.
SipB is secreted through the bacterial T3SS and is typically conserved among Salmonella enterica serovars, with
Genetic and functional studies show that sipB is important for full virulence; strains lacking sipB often exhibit
See also: Type III secretion system; SipA; SipC; Salmonella pathogenicity island 1.