SerotoninWreuptakeHemmern

Serotonin Reuptake Inhibitors (SRIs) are a class of antidepressant medications that work by increasing the levels of serotonin, a neurotransmitter, in the brain. Serotonin is involved in mood regulation, appetite, sleep, and other functions. SRIs prevent the reabsorption of serotonin by the presynaptic neuron, thereby increasing the availability of serotonin in the synaptic cleft. This mechanism helps to improve mood and alleviate symptoms of depression and anxiety.

Common SRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), and escitalopram (Lexapro). These medications are typically taken orally and have a relatively slow onset of action, often requiring several weeks to achieve full therapeutic effects. SRIs are generally well-tolerated, but they can cause side effects such as nausea, dizziness, and sexual dysfunction. Long-term use may also increase the risk of serotonin syndrome, a potentially life-threatening condition.

SRIs are often prescribed for the treatment of major depressive disorder, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, and premenstrual dysphoric disorder. They are generally considered first-line treatment options due to their effectiveness and relatively low risk of side effects compared to older antidepressant classes. However, individual responses to SRIs can vary, and some patients may require alternative treatments or combinations of medications to achieve optimal results.