Ser37

Ser37 refers to the serine amino acid located at position 37 in a protein sequence. The single-letter code S stands for serine. Residue numbering is relative to the protein sequence and can be affected by initiator methionine removal, signal peptide cleavage, or alternative splicing, so Ser37 may represent different residues in different isoforms or species.

Serine residues contain a hydroxyl group, making them common sites for post-translational modification such as phosphorylation and O-linked glycosylation. The presence of Ser37 can influence local structure through hydrogen bonding and can participate in catalytic or binding interactions, depending on context.

As a concrete example, in the human tumor suppressor protein p53, Ser37 is among phosphorylation sites that respond to genotoxic stress. Phosphorylation at Ser33/Ser37 is linked to altered p53 activity and regulation of protein interactions, contributing to the DNA damage response.

In protein annotation and proteomics, Ser37 is typically denoted as S37; modifications are noted as pS37 when phosphorylated. The functional significance of Ser37 is therefore highly context-dependent, varying with the protein and cellular conditions.