Sec61G
SEC61G is a human gene that encodes the gamma subunit of the Sec61 translocon, a core component of the protein-conducting channel in the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a heterotrimer consisting of Sec61α, Sec61β, and Sec61γ; SEC61G provides the small gamma subunit that associates with the other subunits to create the channel through which nascent polypeptides are imported into the ER lumen or integrated into the ER membrane.
The gamma subunit is a small integral membrane protein. Although the precise role of SEC61G is still
Conservation and expression: SEC61G is conserved across eukaryotes, reflecting the essential nature of ER protein translocation.
Clinical significance: Alterations of SEC61G, including copy number gains and elevated expression, have been reported in