Sec61G

SEC61G is a human gene that encodes the gamma subunit of the Sec61 translocon, a core component of the protein-conducting channel in the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a heterotrimer consisting of Sec61α, Sec61β, and Sec61γ; SEC61G provides the small gamma subunit that associates with the other subunits to create the channel through which nascent polypeptides are imported into the ER lumen or integrated into the ER membrane.

The gamma subunit is a small integral membrane protein. Although the precise role of SEC61G is still being studied, it is believed to contribute to the stability of the Sec61 complex and may influence channel gating or substrate specificity, complementing the functions of the larger Sec61α subunit and the Sec61β subunit.

Conservation and expression: SEC61G is conserved across eukaryotes, reflecting the essential nature of ER protein translocation. In humans, the gene is expressed in multiple tissues consistent with the widespread need for secretory and membrane protein production.

Clinical significance: Alterations of SEC61G, including copy number gains and elevated expression, have been reported in some cancers. Such changes may be linked to tumor biology or prognosis in certain contexts, and SEC61G is sometimes discussed in relation to EGFR signaling networks and ER homeostasis. However, the clinical implications are not fully established and require further study.