Sec24A
Sec24A, also known as transmembrane emp24 domain-containing protein 7 (TMED7), is a protein encoded by the SEC24A gene in humans. It is a member of the SEC24 family, integral components of the coat protein complex II (COPII), which is essential for the transport of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus.
The SEC24A protein functions primarily as a cargo adaptor, recognizing specific export signals on cargo proteins
Structurally, SEC24A features multiple domains that enable interactions with both cargo proteins and other COPII components.
Mutations or dysregulation of SEC24A can impact cellular homeostasis and have been associated with various diseases,
Overall, SEC24A plays a vital role in cellular logistics, contributing to the proper functioning of the secretory