Sartans
Sartans, or angiotensin II receptor blockers (ARBs), are a class of antihypertensive medications that selectively block the angiotensin II type 1 (AT1) receptor. This prevents angiotensin II–mediated vasoconstriction and aldosterone release, leading to vasodilation and reduced blood pressure. Unlike ACE inhibitors, ARBs do not inhibit bradykinin breakdown, so they are less likely to cause cough or angioedema, though such effects can still occur.
Common agents include losartan, valsartan, irbesartan, candesartan, telmisartan, olmesartan, and eprosartan. Many are taken by mouth;
Clinical uses include hypertension, heart failure with reduced ejection fraction, and slowing progression of diabetic nephropathy
Adverse effects are generally mild but include hyperkalemia, dizziness, hypotension, and, less commonly, angioedema. Drug interactions