SWI3

SWI3, also known as SWI3H, is a protein that in humans is encoded by the SWI3 gene. This gene is located on chromosome 17 and spans about 100 kilobases. The SWI3 protein is a member of the SWI/SNF chromatin remodeling complex, which plays a crucial role in regulating gene expression by altering the structure of chromatin, the complex of DNA and proteins that makes up chromosomes.

The SWI3 gene is highly conserved across species, indicating its importance in various biological processes. Mutations in the SWI3 gene have been associated with several genetic disorders, including Smith-Magenis syndrome, a rare genetic disorder characterized by intellectual disability, seizures, and distinctive facial features. Additionally, SWI3 has been implicated in cancer, where it can act as either a tumor suppressor or an oncogene, depending on the context.

The SWI3 protein is composed of several domains, including an N-terminal domain, a central ATPase domain, and a C-terminal domain. The ATPase domain is responsible for the energy-dependent remodeling of chromatin, while the other domains contribute to the protein's stability and interaction with other components of the SWI/SNF complex.

Research on SWI3 and its role in chromatin remodeling continues to be an active area of study, with ongoing efforts to understand its functions and potential as a therapeutic target for various diseases.