SPM2

SPM2, also known as Splicing Factor 2, is a protein that plays a crucial role in the process of RNA splicing. It is a component of the spliceosome, the molecular machinery responsible for removing introns from pre-mRNA and joining exons together to form mature messenger RNA (mRNA). This maturation of mRNA is a fundamental step in gene expression, allowing for the correct translation of genetic information into proteins.

The SPM2 protein is a highly conserved member of the serine/arginine-rich (SR) protein family. These proteins are characterized by the presence of serine and arginine residues in specific domains, which are important for their interactions with RNA and other proteins involved in splicing. SPM2's structure includes an RNA recognition motif (RRM) and a RS domain, enabling it to bind to pre-mRNA and recruit other splicing factors.

Dysregulation of SPM2 function has been linked to various human diseases, including certain types of cancer and neurological disorders. Alterations in splicing patterns, often caused by mutations or abnormal expression of splicing factors like SPM2, can lead to the production of aberrant proteins with altered functions or truncated forms, contributing to disease pathogenesis. Research into SPM2 and its role in splicing continues to advance our understanding of gene regulation and has potential implications for therapeutic interventions.