SNX1guided

SNX1guided is a term used in cell biology to describe a model or framework in which Sorting Nexin 1 (SNX1) acts as a guiding factor in endosomal membrane trafficking and cargo sorting. The concept emphasizes the role of SNX1 in shaping membrane tubules and selecting cargo during retrograde transport from endosomes to the trans-Golgi network or to the plasma membrane, typically in conjunction with the retromer complex.

Background: SNX1 is a member of the sorting nexin family characterized by a phox homology (PX) domain that binds phosphoinositides and a BAR domain that helps tubulate membranes. In endosomal trafficking, SNX1 commonly forms complexes with SNX2 and with core retromer components such as VPS26, VPS29, and VPS35 to mediate cargo retrieval.

Definition in practice: In SNX1guided studies, researchers examine how SNX1's lipid interactions, curvature-sensing properties, and protein-protein interactions influence the routing of specific cargo molecules within the endosomal network. This may involve analyzing how SNX1 coordinates with other sorting nexins, retromer adapters, and accessory factors to determine whether cargo is recycled to the plasma membrane or retrieved to the Golgi.

Status and scope: SNX1guided is not a formally defined pathway in standard nomenclature, but rather a descriptive label appearing in some review articles and experimental discussions to capture SNX1-centered guidance of trafficking decisions. As such, it is a topic of ongoing investigation rather than a settled mechanism.

See also: Sorting Nexin, SNX-BAR proteins, Retromer, Endosome, Membrane trafficking.