SIRP
Signal-regulatory protein (SIRP) refers to a family of cell-surface receptors in the immunoglobulin superfamily, primarily expressed on myeloid cells. The best characterized member is SIRPα (also called CD172a). Other family members include SIRPβ and SIRPγ, with species-specific differences in expression.
Structure and signaling: SIRP proteins are type I transmembrane glycoproteins with two (or three) extracellular immunoglobulin-like
Function and interaction with CD47: The extracellular interaction with CD47 serves as a "don't eat me" signal.
Clinical relevance: Disruption of the CD47-SIRPα interaction is being explored as a cancer therapy to promote
Genetic and species variation: SIRP family shows species- and cell-type differences in expression and function. In