SCFbetaTrCP
SCFbetaTrCP refers to a class of ubiquitin ligase complexes within the SCF (Skp1-Cullin-F-box) family, in which the F-box protein beta-transducin repeat-containing protein (β-TrCP) serves as the substrate receptor. The SCFβTrCP ligases direct the ubiquitination and subsequent proteasomal degradation of a subset of phosphorylated substrates, thereby regulating diverse cellular processes.
The complex is composed of the core SCF scaffold—Cullin-1, Skp1, and the RING finger protein Roc1/Rbx1—together
β-TrCP recognizes phosphorylated degron motifs in target proteins, commonly a DSGxxS or similar phosphodegron. Substrates are
Key substrates include IκBα, regulating NF-κB signaling; β-catenin, influencing Wnt signaling; Emi1, Cdc25A, and Claspin, which
Dysregulation of SCFβTrCP activity has been linked to cancer and inflammatory diseases, reflecting its broad role