S100A2

S100A2, also known as calgranulin A, is a member of the S100 family of calcium-binding proteins. These proteins are characterized by their ability to bind calcium ions and are involved in a variety of cellular processes, including cell proliferation, differentiation, and motility. S100A2 is expressed in various tissues, including the epidermis, mammary gland, and prostate.

Research has indicated that S100A2 plays a role in cell cycle regulation and apoptosis. It has been implicated in tumor suppression, with decreased expression observed in several types of cancer, such as breast, ovarian, and lung cancers. Conversely, elevated levels of S100A2 have been associated with more aggressive tumor phenotypes and poorer prognosis in some cases.

The precise mechanisms by which S100A2 exerts its effects are still being investigated, but it is known to interact with various proteins, including p53 and actin. These interactions are thought to mediate its influence on cellular functions. Studies are exploring the potential of S100A2 as a biomarker for cancer diagnosis and prognosis, as well as a therapeutic target for cancer treatment. Its involvement in inflammatory responses is also an area of ongoing research.