RecAdependent
RecA-dependent refers to cellular processes in bacteria that require the RecA recombinase to function. RecA is a central enzyme in homologous recombination and DNA damage tolerance, capable of forming nucleoprotein filaments on single-stranded DNA and promoting strand exchange with a homologous duplex. This activity underpins accurate repair of damaged DNA and genetic recombination.
RecA-dependent pathways rely on loading proteins such as RecBCD or RecFOR to establish RecA filaments at DNA
A major RecA-dependent process is the bacterial SOS response, a coordinated transcriptional program triggered by extensive
RecA is also involved in replication restart through recombination-mediated mechanisms that help restart stalled forks, preserving